张文灿 职       称：长聘教轨副教授，课题组长 所属学科：动物科学 研究方向：1. 病原微生物与适应性免疫系统的互作机制                  2. T细胞的分化调控及其介导的免疫响应 电子信箱：wenczhang@sjtu.edu.cn 联系地址：农生学院A楼3-405

 

个人简历

张文灿，4688美高梅集团唯一长聘教轨副教授，博士生导师，课题组组长（独立PI），入选2023年上海市海外高层次人才。2019年博士毕业于新加坡国立大学（National University of Singapore），2019-2023年于美国希望之城国家医学中心 (City of Hope National Medical Center) 从事博士后研究。2024年1月加入4688美高梅集团唯一。长期聚焦免疫学、分子生物学及食品科学，具有突出的多学科研究背景。共发表SCI论文18篇，其中第一作者文章12篇，包括PNAS，Science Advances，Food Research International等。课题组聚焦动物科学与免疫调控，研究方向涉及1）病原微生物与适应性免疫系统的互作机制; 2) T细胞的分化调控及其介导的免疫响应；3）家畜炎性疾病的发病机理及药物研制。

 

教育工作经历

2015-2019， 新加坡国立大学，博士

2019-2023， 美国希望之城国家医学中心，博士后

2024-至今， 4688美高梅集团唯一，副教授、博士生导师

 

主要研究成果

论文

1. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., & Sun, Z. (2023). Regulatory function of steroid receptor coactivators (SRCs) in cell metabolism: implications for cancer and immunity. Critical Reviews in Immunology. (Under review)

2. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., Feng, M., Wang, Y., Ann, D., Gwack Y., Shang, W., & Sun, Z. (2023). SRC2 controls CD4⁺ T cell activation via stimulating c-Myc mediated up-regulation of amino acid transporter Slc7a5. Proceedings of the National Academy of Sciences (PNAS), 120(18), e2221352120 (Direct Submission). (IF=12.79)

3. Zhang, W., Cao, X., Zhong, X., Wu, H., Feng, M., Gwack Y., & Sun, Z. (2022). Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via upregulating Nr4a2. Science Advances, 8 (24), eabn7662. (IF= 14.957)

4. Zhang, W., Chen, J., Lu, Y. & Liu, S. (2022). Pre-treatment of coconut kernels by proteases to modulate the flavour of coconut oil. Food Bioscience, 101736. (IF= 5.318)

5. Zhang, W., Xu, C., & Liu, S. (2019). Aroma modulation of vegetable oils - a review. Critical Reviews in Food Science and Nutrition, 1-14. (IF= 11.208)

6. Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Solid-state fermentation of palm kernels by Yarrowia lipolytica modulates the aroma of palm kernel oil. Scientific Reports, 9(1), 2538. (IF= 4.996)

7. Zhang, W., Leong, S. M., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2018). Viscozyme L pretreatment on palm kernels improved the aroma of palm kernel oil after kernel roasting. Food Research International, 107,172-181. (IF= 7.425)

8. Zhang, W., & Liu, S. (2018). Pretreatment of palm kernels with proteases modified volatile flavor compounds of palm kernel oil. Journal of Food Biochemistry, 2018: e12622. (IF= 3.654)

9. Zhang, W., Zhao F., Yang, T., & Liu, S. (2017). Protease/peptidase (Flavourzyme) pretreatment on palm kernels improves the aroma of resultant palm kernel oil after kernel roasting. European Journal of Lipid Science and Technology, 119, 1600460. (IF= 3.196)

10. Zhang, W., Zhao, F., Yang, T., Zhao, F., & Liu, S. (2017). Celluclast 1.5 L pretreatment enhanced aroma of palm kernels and oil after kernel roasting. Journal of the Science of Food and Agriculture, 97(15), 5146-5157. (IF= 4.125)

11. Zhang, W., Zhao, F., Zhao, F., Yang, T., & Liu, S. (2017). Pentopan mono BG pretreatment of palm kernels modified the aroma of palm kernel oil after kernel roasting. LWT-Food Science and Technology, 86, 577-585. (IF= 6.056)

12. Zhang, W., Wang, R., Yuan, Y., Yang, T., & Liu, S. (2016). Changes in volatiles of palm kernel oil before and after kernel roasting. LWT-Food Science and Technology, 73, 432-441. (IF= 6.056)

13. Zhong, X., Wu, H., Ouyang, C., Zhang, W., Shi, Y., Wang, YC., Ann, D., Gwack, Y., Shang, W., & Sun, Z. (2023). SRC-2 stimulates CD8+ T cell activation by up-regulating PGC-1α critical for mitochondrial function. Cancer Immunology Research (Accepted). (IF= 12.02)

14. Zhong, X., Wu, H., Zhang, W., Gwack, Y., Shang, W., Lee, K. O., Isakov, N., He, Z., & Sun, Z. (2022). Decoupling the role of RORγt in the differentiation and effector function of TH17 cells. Science advances, 8(42), eadc9221. (IF= 14.957)

15. Cao, X., Wang, Y., Zhang, W., Zhong, X., Gunes, GE., Dang, J., Wang, J., Epstein, AL., Querfeld, C., Sun, Z., Rosen, ST., & Feng, M. (2022). Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression. Blood, 139(22) (IF= 25.476)

16. Cao, X., Chen, J., Li, B., Dang, J., Zhang, W., Zhong, X., Wang, C., Raoof, M., Sun, Z., Yu, J., Fakih, MG. & Feng, M. (2022). Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. Science Advances, 8(11): eabl9171. (IF= 14.957)

17. Cao, X, Cao, L, Zhang, W., Lu, R, Bian, JS, & Nie, X. (2020). Therapeutic potential of sulfurcontaining natural products in inflammatory diseases. Pharmacology & Therapeutics, 107687 (IF= 13.4)

18. Cao, X., Zhang, W., Moore, PK., & Bian, J. Protective smell of hydrogen sulfide and polysulfide in cisplatin induced nephrotoxicity (2019). International Journal of Molecular Sciences, 20(2). (IF= 6.208)

 

获奖情况

上海市海外高层次人才

 

人员招聘

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