黎   凌 职    称：副研究员 所属学科：园艺学 研究方向：       1. 植物次生代谢 2. 植物多细胞腺毛发育 电子信箱：liling@sjtu.edu.cn 联系地址：农生大楼1-411

 

个人简介

1998年毕业于南开大学生物化学及分子生物学专业，获学士学位。2008年毕业于中科院上海植物生理生态研究所，获博士学位。同年进入任上海交通4688美高梅集团唯一工作，先后任助理研究员、副研究员。

 

研究工作

从事植物次生代谢相关的研究，主要研究工作包括：

1.以青蒿、烟草、番茄、地钱作为底盘进行植物次生代谢和合成生物学的研究。

2.以青蒿为模式，探索次生代谢产物合成相关的植物多细胞腺毛发育模式。

主持或参加科研项目：

1. 国家自然科学基金委员会，面上项目，32070329，AaMYB16-AaHD1-AaMYB5复合体通过调控青蒿腺毛起始发育影响青蒿素合成的分子机理研究，2021/01-2024/12，58万元，在研，主持。

2. 科技部，国家重点研发计划，2018YFA0900604，重要活性代谢物在植物底盘中的高效定向合成，2019/07-2024/06，594万元，在研，参加。

3. 美国比尔和梅琳达盖茨基金会、OPP1199872、Identification and functional characterization of putative enzymes involved in the artemisinin biosynthesis from Artemisia annua，2018/09-2020/02，75万美元，已结题，参加。

4. 国家自然科学基金委员会，面上项目，31770327，AaMYB2介导光信号和茉莉酸信号互作调控青蒿素合成的分子机理研究，2018/01-2021/12，60万元，在研，主持。

5. 上海市科委，自然基金面上项目，16ZR1418000，光信号调控青蒿素合成的分子机理研究，2016/7-2019/6，20万元，已结题，主持。

近期代表性论文： 

1. Xie L^#, Yan T^#, Li L^#, Chen M, Hassani D, Li Y, Qin W, Liu H, Chen T, Fu X, Shen Q, Rose JKC, Tang K^*. An HD-ZIP-MYB complex regulates glandular secretory trichome initiation in Artemisia annua. New Phytol. 2021 May 27. doi: 10.1111/nph.17514.

2. Xie L, Yan T, Li L, Chen M, Ma Y, Hao X, Fu X, Shen Q, Huang Y, Qin W, Liu H, Chen T, Hassani D, Kayani SL, Rose JKC, Tang K^*. The WRKY transcription factor AaGSW2 promotes glandular trichome initiation in Artemisia annua. J Exp Bot. 2021 Feb 27;72(5):1691-1701.

3. Li, L., Hao, X., Liu, H., Wang, W., Fu, X., Ma, Y., Shen, Q., Chen, M., and Tang, K.X^*. (2019). Jasmonic acid-responsive AabHLH1 positively regulates artemisinin biosynthesis in Artemisia annua. Biotechnology and applied biochemistry 66, 369-375.

4. Hao, X., Zhong, Y., Ni Tzmann, H.W., Fu, X., Yan, T., Shen, Q., Chen, M., Ma, Y., Zhao, J., Osbourn, A., Li, L^*., and Tang, K.X^*. (2019). Light-Induced Artemisinin Biosynthesis Is Regulated by the bZIP Transcription Factor AaHY5 in Artemisia annua. Plant & cell physiology 60, 1747-1760.

5. Ma, Y.N., Xu, D.B., Li, L., Zhang, F., Fu, X.Q., Shen, Q., Lyu, X.Y., Wu, Z.K., Pan, Q.F., Shi, P., Hao, X.L., Yan, T.X., Chen, M.H., Liu, P., He, Q., Xie, L.H., Zhong, Y.J., Tang, Y.L., Zhao, J.Y., Zhang, L.D., Sun, X.F., and Tang, K.X^*. (2018). Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua. Sci Adv 4, eaas9357.

6. Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., Lv, Z., Lu, X., Zhang, F., Jiang, W., Ma, Y., Chen, M., Hao, X., Li, L., Tang, Y., Lv, G., Zhou, Y., Sun, X., Brodelius, P.E., Rose, J.K.C., and Tang, K.X^*. (2018). The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis. Mol Plant 11, 776-788.

7. Yan, T^#., Li, L^#., Xie, L., Chen, M., Shen, Q., Pan, Q., Fu, X., Shi, P., Tang, Y., Huang, H., Huang, Y., Huang, Y., and Tang, K.X^*. (2018). A novel HD-ZIP IV/MIXTA complex promotes glandular trichome initiation and cuticle development in Artemisia annua. The New phytologist 218, 567-578.

8. Shi, P., Fu, X., Shen, Q., Liu, M., Pan, Q., Tang, Y., Jiang, W., Lv, Z., Yan, T., Ma, Y., Chen, M., Hao, X., Liu, P., Li, L., Sun, X., and Tang, K.X^*. (2018). The roles of AaMIXTA1 in regulating the initiation of glandular trichomes and cuticle biosynthesis in Artemisia annua. The New phytologist 217, 261-276.

9. Wang, S., Li, L., Xu, P., Lian, H., Wang, W., Xu, F., Mao, Z., Zhang, T., and Yang, H.Q ^*. (2018). CRY1 interacts directly with HBI1 to regulate its transcriptional activity and photomorphogenesis in Arabidopsis. J Exp Bot 69, 3867-3881.

10. Wang, W., Lu, X., Li, L., Lian, H., Mao, Z., Xu, P., Guo, T., Xu, F., Du, S., Cao, X., Wang, S., Shen, H., and Yang, H.Q^*. (2018). Photoexcited CRYPTOCHROME1 Interacts with Dephosphorylated BES1 to Regulate Brassinosteroid Signaling and Photomorphogenesis in Arabidopsis. Plant Cell 30, 1989-2005.

11. Yan, T., Chen, M., Shen, Q., Li, L., Fu, X., Pan, Q., Tang, Y., Shi, P., Lv, Z., Jiang, W., Ma, Y.N., Hao, X., Sun, X., and Tang, K.X^*. (2017). HOMEODOMAIN PROTEIN 1 is required for jasmonate-mediated glandular trichome initiation in Artemisia annua. The New phytologist 213, 1145-1155.

12. Hao, X., Zhong, Y., Fu, X., Lv, Z., Shen, Q., Yan, T., Shi, P., Ma, Y., Chen, M., Lv, X., Wu, Z., Zhao, J., Sun, X., Li, L^*., and Tang, K.X^*. (2017). Transcriptome Analysis of Genes Associated with the Artemisinin Biosynthesis by Jasmonic Acid Treatment under the Light in Artemisia annua. Front Plant Sci 8, 971.

13. Zhang, F^#., Liu, S^#., Li, L^#., Zuo, K., Zhao, L., and Zhang, L^*. (2016). Genome-Wide Inference of Protein-Protein Interaction Networks Identifies Crosstalk in Abscisic Acid Signaling. Plant Physiol 171, 1511-1522.

14. Lian, H.L., He, S.B., Zhang, Y.C., Zhu, D.M., Zhang, J.Y., Jia, K.P., Sun, S.X., Li, L., and Yang, H.Q^*. (2011). Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism. Genes & development 25, 1023-1028.

15. Li, L., Shi, Z.Y., Li, L., Shen, G.Z., Wang, X.Q., An, L.S., and Zhang, J.L^*. (2010). Overexpression of ACL1 (abaxially curled leaf 1) increased Bulliform cells and induced Abaxial curling of leaf blades in rice. Mol Plant 3, 807-817.