涂晓雨 职       称：长聘教轨副教授，博士生导师 所属学科：园艺学 研究兴趣：作物高光效分子调控 电子信箱：xiaoyutu@sjtu.edu.cn 联系地址：农生科创大楼B315A室

 

个人简介：

涂晓雨，4688美高梅集团唯一博士生导师，独立课题组长。博士毕业于香港中文大学，曾于美国康奈尔大学Boyce Thompson Institute访学。以第一/通讯作者在Molecular Plant、Nature Communications（3篇）、Plant Communications等期刊发表论文，其中3篇入选ESI高被引、2篇被评为热点。近年来主持国家自然科学基金委国际（地区）合作研究项目、面上项目、青年科学基金项目（C类），交大2030计划项目（C类）等；入选上海市领军（海外）青年人才计划、上海市农业科技创新人才培育（春蕾）计划等。现任Physiologia Plantarum期刊handling editor，承担本科生《生物信息学》课程教学。

 

研究工作：

C4植物代表着陆地上一类高生产力植物类群，通过叶肉细胞与维管束鞘细胞的协作形成高效碳浓缩机制，在资源利用和逆境适应性上显著优于C3植物，其形成依赖遗传与表观遗传调控。染色质可及性与组蛋白修饰为转录因子结合顺式作用元件提供结构基础，而复杂的冗余互作实现基因表达的时空特异性和稳健灵活的平衡。解析C4光合调控不仅帮助理解这一经典趋同进化想象的关键所在，也为高光效作物育种提供理论支持。课题组综合利用（单细胞）多组学测序技术和人工智能分析方法，系统解析C4光合作用的分子调控及其特殊功能性状塑造，主要包含以下科学问题：

1. C4光合基因的动态调控网络与细胞分工；
2. 光合基因跨物种调控的适应性进化；
3. 作物高光效合成的调控策略工程设计及应用。

 

在研项目：

1. 国家自然科学基金国际（地区）合作研究项目，2025-2028
2. 国家自然科学基金面上项目，2024-2027
3. 国家自然科学基金青年科学基金项目（C类），2022-2024
4. 上海市农业科技创新项目，2024-2026
5. 宁夏回族自治区重点研发计划项目课题，2024-2026
6. 交大2030计划（C类）项目，2024-2025

 

论文发表（†, co-first; *, corresponding; in bold, Tu lab members）：

16. Zhao, C., Yang, J., Ni, A., Chen, H., Su, H., Cheng, Y., Li, X., Zhong, L., Fang, D., Sun, H., Yi, J., Wang, Y., Wang, Y., Ming-ju A.L., Ni, X., Chen, L., Li, H., Yu, G., Wang, Y., Chen, R., Yu, H., Shao, W., Sun, H., Bai, Y., Li, C., Dong, Y., Zou, C., Tu, X., Ma, S., Guo, X., Zhang, G., Wang, P., Liu, H., Wei, T., Gu, Y., Zhu, X., Xu, X.; Comparative spatiotemporal single cell transcriptomes reveal rewiring of pre-existing regulations during emergence of Kranz anatomy in C₄ grasses; bioRxiv

15. Zhu, Y., Ngan, H., Zhu, T., Nan, L., Li, W., Xiao, Y., Zhuo, L., Chen, D., Tu, X., Gao, K., Yan, J., Zhong, S., Yang, N.; Pan-cistrome analysis of the leaf accessible chromatin regions of 214 maize inbred lines; bioRxiv

14. Yan, H., Mendieta, J.P., Zhang, X., Liang, Y., Luo, Z., Marand, A.P., Wang Y., Tu, X., Zhong, S., Wessler, S.R., Schmitz, R.J.^*; Evolution of plant cell-type-specific cis-regulatory elements; bioRxiv

13. Mendieta, J.P., Tu, X., Jiang, D., Yan, H., Zhang, X., Marand, A.P., Zhong, S., Schmitz, R.J.^*; Investigating the cis-regulatory basis of C₃ and C₄ photosynthesis in grasses at single-cell resolution; PNAS, 2024, 121(40):e2402781121

12. Tu, X., Ren, S.^†, Shen, W.^†, Li, J.^†, Li, Y., Li, C., Li, Y., Zong, Z., Xie, W., Grierson, D., Fei, Z., Giovannoni, J., Li, P.^*, Zhong, S.^*; Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence; Nature Communications, 2022, 13:7632 (Nature Communications featured article：http://www/nature.com/subjects/plant-genetics/ncomms)

11. Zhang, Y., Ma, M.^†, Liu, M.^†, Sun, A.^†, Zheng, X., Liu, K., Yin, C., Li, C., Jiang, C.^*, Tu, X.^* (co-corresponding), Fang, Y.^*; Histone H2A monoubiquitination marks are targeted to specific sites by cohesin subunits in Arabidopsis; Nature Communications, 2023, 14:1209 (Nature Communications featured article：http://www/nature.com/subjects/plant-evolution/ncomms)

10. Tu, X., Marand, A.P.^†, Schmitz, R.J.^*, Zhong, S.^*; A combinatorial indexing strategy for low-cost epigenomic profiling of plant single cells; Plant Communications, 2022, 3:100308

9. Dai, X., Tu, X.^† (co-first), Du, B., Dong, P., Sun, S., Wang, X., Sun, J., Gang, L., Lu, T.^*, Zhong, S.^*, Li, P.^*; Chromatin and regulatory differentiation between bundle sheath and mesophyll cells in maize; Plant Journal, 2022, 109(3):675-692

8. Sun, A., Yin, C., Ma, M., Zhou, Y., Zheng, X., Tu, X., Fang, Y.; Feedback regulation of auxin signaling through the transcription of H2A.Z and deposition of H2A.Z to SMALL AUXIN UP RNAs in Arabidopsis; New Phytologist, 2022, 236(5):1721-1733

7. Wang, X., Wang, X.^†*, Sun, S., Tu, X., Lin, K., Qin, L., Wang, X., Li, G.^*, Zhong, S.^*, Li, P.^*; Characterization of regulatory modules controlling leaf angle in maize; Plant Physiology, 2022, 190(1):500-515

Before SJTU

6. Tu, X., Mejía-Guerra, M.K.^†*, Valdes Franco, J.A., Tzeng, D., Chu, P., Shen, W., Wei, Y., Dai, X., Li, P.^*, Buckler, E.S., Zhong, S.^*; Reconstructing the maize leaf regulatory network using ChIP-seq data of 104 transcription factors; Nature Communications, 2020, 11:5089

5. Dong, P., Tu, X.^† (co-first), Li, H., Zhang, J., Grierson, D., Li, P.^*, Zhong, S.^*; Tissue-specific Hi-C analyses of rice, foxtail millet and maize suggest non-canonical function of plant chromatin domains; Journal of Integrative Plant Biology, 2020, 62(2):201-217

4. Dong, P., Tu, X., Liang, Z., Kang, B., Zhong, S.^*; Plant and animal chromatin three-dimensional organization: similar structures but different functions; Journal of Experimental Botany, 2020, 71(17):5119-5128

3. Dai, X., Xu, Z., Liang, Z., Tu, X., Zhong, S., Schnable, J.C.^*, Li, P.^*; Non‐homology‐based prediction of gene functions in maize (Zea mays ssp. mays); Plant Genome, 2020, 13(2):e20015

2. Dong, P., Tu, X.^† (co-first), Chu, P.^†, Lü, P., Zhu, N., Grierson, D., Du, B., Li, P.^*, Zhong, S.^*; 3D chromatin architecture of large plant genomes determined by local A/B compartments; Molecular Plant, 2017, 10(12):1497-1509

1. Ding, Z., Weissmann, S., Wang, M., Du, B., Huang, L., Wang, L., Tu, X., Zhong, S., Myers, C., Brutnell, T.P., Sun Q.^*, Li, P.^*; Identification of Photosynthesis-Associated C₄ Candidate Genes through Comparative Leaf Gradient Transcriptome in Multiple Lineages of C₃ and C₄ Species; PLoS ONE, 2015, 10:e0140629

发明专利：

1. 涂晓雨，李杨美汇，张优，李传顺，龙正标：一种基于染色质预富集的高效植物ChIPmentation方法，申请号：2025100973451

 

人才培养：

2020级本科生，刘运哲，毕业去向：苏黎世联邦理工学院（ETH）

2021级硕士生，王天淼，毕业去向：中共青岛市黄岛区委员会组织部

2021级本科生，马晴川，在读

2022级硕士生，李亿宁，在读

2022级博士生，李杨美汇，在读

2023级硕士生，李铭璇，在读

2023级硕转博，杨乐意，在读

2023级博士生，李传顺，在读

2023级博士后，张优，在站

2024级博士生，龙正标，在读

2025级博士后，林堪德，在站