PI组长：
     孙向军  研究员    

组员：
     牛宇戈 陆维盈 张亚琼 高博彦  

研究方向：
    食品化学及功能性组分

主要研究领域：

(1)食品中天然小分子及大分子结构鉴定及构效性关系；(2)食品功能组分健康效应以及干预机理；(3)递送体系的可控构建与评价；(4)食品加工过程中产生的有害物质化学形成机理及毒性机理；(5)化学计量学快速分析食品品质  

PI研究组代表性成果：  

1.主要科研项目：

(1)国家自然科学基金面上项目《玉米醇溶蛋白/酪蛋白酸钠/果胶复合颗粒的可控构建及其用于食品营养递送体系的研究》，2019.1-2020.12；

(2)国家自然科学基金面上项目《网络互穿型黑豆皮可溶性膳食纤维双交联复合胶的形成机制与功能研究》，2018.1-2021.12；

(3)国家自然科学基金面上项目《原花青素B2通过XBP1-s干预高脂环境诱导RPE细胞氧化应激机制研究》，2016.1-2019.12；

(4)“十三五”国家重点研发计划子课题《食品中化学危害因子非定向筛查技术研究》，2019.1-2020.12；

(5)“十三五”国家重点研发计划子课题《水产品营养品质保持与调控机制 》，2019.1-2020.12；

(6)“十三五”国家重点研发计划子课题《风险因子与代谢标志物表征研究》，2018.1-2020.12；

(7)“十三五”国家重点研发计划子课题《预制食品关键营养素相互作用及对营养品质的影响》，2018.7-2020.12；

(8)“十三五”国家重点研发计划子课题《番茄酱汁类制品加工过程中质量品质控制技术》，2016.12-2020.12

2.发明专利

(1)《结构脂OPO的应用》，201810354026.4

(2)《一种经改性的蛋白及其制备方法和应用》，201610237860.6

(3)《一种除去3-氯丙二醇酯的方法》，201610392375.6

(4)《姜黄素复合颗粒及其制备方法和应用》，ZL201510819903.7

(5)《一种新的酪蛋白衍生物及其制备方法》，ZL201410312926.4

(6)《一种酚类化合物肝毒性快速预测模型的构建方法》，201310461025.7

(7)《一种从番茄皮渣中提取番茄红素的方法》，CN109574784A

(8)《一种番茄皮可溶性膳食纤维的互穿胶体及其制备方法》，CN106800660A

3.代表论著

(1) Gu, M., Fang, H., Gao, Y., Su, T., Niu, Y.* Liangli Yu. Characterization of enzymatic modified soluble dietary fiber from tomato. Food Hydrocolloids 2020, 99:105321

(2) Choe, U., Li, Y., Gao, B.,* Yu, L., Wang, T.T.Y., Sun, J., Chen, P., Liu, J., Yu, L.   Chemical composition of cold-pressed milk thistle seed flour extract, and its potential health beneficial properties. Food & Function 2019, just accepted.

(3) Niu,Y., * Xia, Q., Li, N., Wang, Z., Yu,L. Gelling and bile acid binding properties of gelatin-alginate gels with interpenetrating polymer networks by double cross-linking. Food Chemistry 2019, 270: 223–228.

(4) Zhang, Y., Wang, B., Wu, Y., Gao,B.,* Yu, L. Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments, Molecules 2019, 24(14): 2535

(5) Gao, B., Holroyd, S., Moore, J., Laurvick, K., Gendel, S., Xie, Z. Opportunities and challenges using non-targeted methods for food fraud detection. Journal of Agriculture and Food Chemistry 2019, 67：8425-8430.

(6) Xue, J., Zhang, Y.,* Huang,G., Liu, J., Slavin, M., Yu, L. Zein-caseinate composite nanoparticles for bioactive delivery using curcumin as a probe compound, Food Hydrocolloids 2018, 83, 25-35

(7) Zhang, Y., Yao, F., Liu, J., Zhou, W., Yu, L.* Synthesis and characterization of alkylated caseinate, and its structure-curcumin loading property relationship in water, Food Chemistry 2018, 244:246-253

(8) Huang, G., Gao, B.,* Xue, J., Cheng, Z., Sun, X., Zhang, Y., Yu, L. Toxicokinetics and metabolism of 3-monochloropropane 1,2-diol (3-MCPD) dipalmitate in Sprague Dawley rats. Journal of Agriculture and Food Chemistry 2018, 66: 11672-11680.

(9) Luo, Y., Zhang, Y., Yuan, F., Gao, B.,* Wang, Z., Yu, L. Triacylglycerols Composition Analysis of Olive Oils by Ultra-Performance Convergence Chromatography Combined with Quadrupole Time-of-Flight Mass Spectrometry. International Journal of Food Science and Technology 2018, 54: 871-879.

(10) Du, L.; Lu, W.*; Cai, Z.; Bao, L.; Hartmann, C.; Gao, B.; & Yu, L.* Rapid detection of milk adulteration using intact protein flow injection mass spectrometric fingerprints combined with chemometrics. Food Chemistry 2018, 240, 573-578.

(11) Xu, Z., Chu, Z., Li, W., Sun, T., Sun, X.* Grape seed extracts attenuate retinal Müller cell gliosis in streptozotocin-diabetic rats, Journal of Functional Foods 2018, 50:45-52

(12) Huang, G., Xue, J., Sun, X.,* Wang, J., Yu, L.* Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p, Toxicology 2018, 406-407:33-43

(13) Gao, B., Luo, Y., Lu, W., Liu, J., Zhang *, Y., Yu *, L.  Triacylglycerol compositions of sunflower, corn and soybean oils examined with supercritical CO₂ ultra-performance convergence chromatography combined with quadrupole time-of-flight mass spectrometry. Food Chemistry 2017, 218: 569-574

(14) Gao, B., Liu, M., Huang, G., Zhang, Z., Zhao, Y., Wang, T.T.Y., Zhang, Y., Liu, J., Yu, L. Absorption, Distribution, Metabolism and Excretion of 3‑MCPD 1‑Monopalmitate after Oral Administration in Rats. Journal of Agricultural and Food Chemistry 2017, 65: 2609-2614

(15) Lu, W.; Liu, J.*; Gao, B.; Lv, X.; Yu, L.* Technical note: Nontargeted detection of adulterated plant proteins in raw milk by UPLC-quadrupole time-of-flight mass spectrometric proteomics combined with chemometrics. Journal of Dairy Science 2017, 100(9): 6980-6986

(16) Zhao, Y., Zhang, Y., Zhang, Z., Liu, J., Wang, Y., Gao, B., Niu, Y., Sun, X.,* Yu, L^*. Formation of 3-MCPD Fatty Acid Esters from Monostearoyl Glycerol and the Thermal Stability of 3-MCPD Monoesters, Journal of Agricultural and Food Chemistry 2016, 64:8918-8926

(17) Liu, M., Huang, G., Wang, T.T.Y., Sun, X.,* Yu, L.* 3-MCPD 1-palmitate induced tubular cell apoptosis in vivo via JNK/p53 pathways，Toxico Sci 2016, 151: 181-192.

(18) Zhang, Z., Gao, B., Zhang, X., Jiang, Y., Xu, X., Yu*, L. Formation of 3-MCPD di- and mono- esters from tristearoylglycerol (TSG), and the potential catalytic effect of Fe²⁺ and Fe³⁺. Journal of Agricultural and Food Chemistry 2015, 63:1839-1848

(19) Zhang, Z., Gao, B., (co-first author), Zhang, X., Jiang, Y., Xu, X., Yu, L.*  Formation of 3-MCPD di- and mono- esters from tristearoylglycerol (TSG), and the potential catalytic effect of Fe²⁺ and Fe³⁺. Journal of Agricultural and Food Chemistry 2015, 63:1839-1848.

(20) Zhang, Y., Niu, Y., Yao, F., Dai,B., Wang, Q., Yu, L.* Preparation of novel cross-linked and octylated caseinates using a biphasic enzymatic procedure and their functional properties, Journal of Agricultural and Food Chemistry 2014, 62(34):8655-8662

(21) Gong, L., Zhang, H., Niu, Y.,* Chen, L., Liu, J., Alaxi, S., Shang, P., Yu, W., Yu, L.* A Novel Alkali Extractable Polysaccharide from Plantago asiatic L. Seeds and Its Radical-Scavenging and Bile Acid-Binding Activities. Journal of Agricultural and Food Chemistry 2015, 63 (2): 569–577

(22) Zhang, Y., Niu, Y., Luo, Y., Ge, M., Yang, T., Yu, L.* Qin Wang, Fabrication, characterization and antimicrobial activities of thymol-loaded zein nanoparticles stabilized by sodium caseinate-chitosan hydrochloride double layers, Food Chemistry 2014,142:269-275

(23) Lu, W.; Jiang, Q.; Shi, H.; Niu, Y.; Gao, B.; Yu, L., Partial least-squares-discriminant analysis differentiating Chinese wolfberries by UPLC–MS and flow injection mass spectrometric (FIMS) fingerprints. Journal of Agricultural and Food Chemistry 2014, 62: 9073-9080.

(24) Zhao Z., Sun, T., Jiang, Y., Wu, L., Cai, X., Sun, X., * Sun, X. * Photooxidative damage in retinal pigment epithelial cells via GRP78 and the protective role of grape skin polyphenols. Food Chem Toxicol 2014,74 : 216–224

(25) Zhou, Q., Gao, B., (co-first author), Zhang, X., Xu, Y., Shi, H., Yu*, L. Chemical profiling of triacylglycerols and diacylglycerols in cow milk fat by ultra-performance convergence chromatography combined with a quadrupole time-of-flight mass spectrometry. Food Chemistry 2014, 143:199-204.